The Laboratory of Human Immuno-Retrovirology (LHIR) is a fundamental and academic research laboratory. The primary objective of this research group is to provide new insights on the life cycle of the human immunodeficiency virus type 1 (HIV-1) and, ultimately, to develop new therapeutic avenues in the fight against this debilitating retroviral infection.
Topics of interest
Immunopathogenesis of NeuroAIDS
- Effects of HIV-1 exposure on cells of the CNS and the blood brain barrier.
- HIV-1 latency in cells of the CNS
- Effects of LRAs and ARVs on cells of the CNS and the blood brain barrier
Interactions between HIV-1 and Other Human Pathogens (funded by CIHR)
- Investigation of the putative interactions between HIV-1 and the protozoan parasite Leishmania.
- Study the modulatory effects of hepatitis C virus with respect to the replicative cycle of HIV.
Study of the Complex Interplay between HIV-1 and its Human Host (funded by CIHR)
- Study of the complex host response that is initiated following HIV infection by performing large-scale gene profile analyses using the microarray chip technology coupled with powerful bioinformatic tools.
Deciphering the complex interconnections between dendritic cells and HIV-1
- Study of the mechanisms leading to transmission of HIV-1 to CD4+ T cells by dendritic cells, the infection of dendritic cells by HIV-1 and the impact of TLR-mediated signals on these phenomenons.
Biochemical, cellular and molecular studies to dissect the contribution of the soluble host carbohydrate binding proteins to HIV-1 pathogenesis (funded by CIHR; collaboration with Dr. Sachiko Sato)
- Determination of the role of galectins in HIV-1 infection of macrophages and CD4+ T cells.
Immunity to HIV
- Definition of the correlates of immune protection against HIV-1 infection using an experimental cell system consisting in tonsillar tissue cultured ex vivo.